Dr. rer. nat Markus Plaumann
Dr. rer. nat. Markus Plaumann
Institut für Biometrie und Medizinische Informatik (IBMI)
2001-2006 | Chemiestudium an der Universität Bremen |
12/2006 | Diplom in Chemie; Diplomarbeit: "Synthese und Charakterisierung lipophiler fluorierter Gd-Kontrastmittel für die molekulare 1H- und 19F-Bildgebung", Universität Bremen, Institut für Organische Chemie, Arbeitsgruppe Instrumentelle Analytik, Prof. Leibfritz |
2007-2010 | Doktorand: "Synthese und Charakterisierung paramagnetischer Kontrastmittel für die molekulare Bildgebung", Universität Bremen, Arbeitsgruppe von Prof. Dr. D. Leibfritz. |
2007-2010 | Dozent für Biochemie in der MTA-Schule, Bremen/Bremerhaven |
2008-2010 | Dozent für Chemie in der MTA-Schule, Bremen/Bremerhaven |
04/2010-03/2011 | Wissenschaftlicher Mitarbeiter an der Universität Bremen im Institut für Organische Chemie bei Prof. Dr. D. Leibfritz. |
seit 01/2011 | Wissenschaftlicher Mitarbeiter (Post-Doc) an der Otto-von-Guericke-Universität Magdeburg im Institut für Biometrie und Medizinische Informatik bei Prof. Dr. Dr. J. Bernarding. Forschungsbereich: Hyperpolarisation, 19F-MR-Bildgebung. |
- Dr. Jonas Warneke, Perdue University, Department of Chemistry, West Lafayette, IN, USA
- Prof. Dr. Andreas Dotzauer, Universität Bremen, Laboratorium für Virusforschung
- Dr. Sven Gottschalk, Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München
- Dr. Vladimir A. Azov, University of the Free State, Department of Chemistry, Bloemfontein, South Africa
- Prof. Dr. Gerd Buntkowsky, TU Darmstadt, Physikalische Chemie
2018
Abstrakt
Temperatursensitive 19F-markierte Moleküle für die 19F-Bildgebung in einem 7 T Ganzkörper MRT-System
In: 49. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik (DGMP) e. V. und 21. Jahrestagung der Deutschen Sektion der International Society for Magnetic Resonance in Medicine (ISMRM) e.V.: 19. - 22. September 2018, Meistersingerhalle, Münchener Strasse 21, 90478 Nürnberg - [Berlin]: [Deutsche Gesellschaft für Medizinische Physik e.V.], 2018, P 20, Seite 282; https://www.dgmp-kongress.de/
SQUID based magnetic resonance imaging for the investigation of in situ and in vivo hyperpolarization techniques
In: European Molecular Imaging Meeting - EMIM 2018, March 20 - 23, 2018, Kursaal San Sebastián, Spain: 13th annual meeting of ESMI, 2018, PS-13-2, insges. 1 Seite; http://www.eventclass.org/contxt_emim2018/online-program/session?s=PS-13
Comparison of the hyperpolarization of different fluorinated aromatic systems via photo-CIDNP
In: An International Conference on Nuclear Hyperpolarization: Sep 2-5 2018, HYP 18, 2018, P 49, Seite 112; https://generic.wordpress.soton.ac.uk/hyp18/abstracts/
Construction of an flow-phantom for MRI based on MR imaging data of a rats head
In: European Molecular Imaging Meeting - EMIM 2018, March 20 - 23, 2018, Kursaal San Sebastián, Spain: 13th annual meeting of ESMI, 2018, #268, insges. 1 Seite; http://www.eventclass.org/contxt_emim2018/online-program/session?s=PO-02
LED-based photo-CIDNP increases 19F signal for MRI
In: 40th FGMR Discussion Meeting: Leipzig, Germany, September 10-13, 2018 - Leipzig, Germany: University of Leipzig, 2018, Poster 93, Seite 215
Big data showroom - ein Konzept für standortübergreifende Kooperationen
In: 63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS): 02.09.-06.09.2018, Osnabrück - Düsseldorf: German Medical Science GMS Publishing House, 2018, DocAbstr. 175, insges. 2 Seiten; http://dx.doi.org/10.3205/18gmds128
Boosting 19F MRI sensitivity by hyperpolarization
In: Joint annual meeting ISMRM-ESMRMB 2018: Paris Expo Porte de Versailles, Paris, France, 16-21 June 2018, SMRT 27th Annual Meeting, 2018, Session Number: MIS-10, insges. 1 Seite; https://www.ismrm.org/18/program_files/MIS10.htm
Hyperpolarisation mittels Parawasserstoff (PHIP&SABRE)
In: 49. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik (DGMP) e. V. und 21. Jahrestagung der Deutschen Sektion der International Society for Magnetic Resonance in Medicine (ISMRM) e.V.: 19. - 22. September 2018, Meistersingerhalle, Münchener Strasse 21, 90478 Nürnberg - [Berlin]: [Deutsche Gesellschaft für Medizinische Physik e.V.], S. 230; https://www.dgmp-kongress.de/
SABRE-based hyperpolarization and substituent effects
In: An International Conference on Nuclear Hyperpolarization: Sep 2-5 2018, HYP 18, 2018, P 104, Seite 167; https://generic.wordpress.soton.ac.uk/hyp18/abstracts/
Begutachteter Zeitschriftenartikel
Total synthesis of mycenarubin A, sanguinolentaquinone and mycenaflavin B and their cytotoxic activities
In: European journal of organic chemistry - Weinheim: Wiley-VCH Verl, 22, S. 2806-2816, 2018; http://dx.doi.org/10.1002/ejoc.201800417
Low-cost LED-based Photo-CIDNP enables biocompatible hyperpolarization of 19 F for NMR and MRI at 7 T and 4.7 T
In: ChemPhysChem: a European journal of physical chemistry and chemical physics - Weinheim: Wiley-VCH Verl, Bd. 19.2018, 19, S. 2453-2456; http://dx.doi.org/10.1002/cphc.201800570
Mutual benefit achieved by combining ultralow-field magnetic resonance and hyperpolarizing techniques
In: Review of scientific instruments: a monthly journal devoted to scientific instruments, apparatus, and techniques - [S.l.]: American Institute of Physics, Bd. 89 (2018), 12, Art.-Nr. 125103, insges. 12 S.; http://dx.doi.org/10.1063/1.5043369
Metamaterial-based transmit and receive system for whole-body magnetic resonance imaging at ultra-high magnetic fields
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 13.2018, 1, Art.-Nr. e0191719, insges. 17 S.; http://dx.doi.org/10.1371/journal.pone.0191719
Parahydrogenbased hyperpolarization for biomedicine
In: Angewandte Chemie / International edition - Weinheim: Wiley-VCH, Bd. 57.2018, 35, S. 11140-11162; http://dx.doi.org/10.1002/anie.201711842
Parawasserstoff-basierte Hyperpolarisierung für die Biomedizin
In: Angewandte Chemie - Weinheim: Wiley-VCH, Bd. 130.2018, 35, S. 11310-11333; http://dx.doi.org/10.1002/ange.201711842
Metabolic and molecular imaging with hyperpolarised tracers
In: Molecular imaging & biology: MIB : the official journal of the Academy of Molecular Imaging - Amsterdam [u.a.]: Elsevier Science, Bd. 20.2018, 6, S. 902-918; http://dx.doi.org/10.1007/s11307-018-1265-0
2017
Abstrakt
Total synthesis of mycenaflavin B and mycenarubin A
In: ESOC 2017 - [Köln, Germany]: [Universität zu Köln, Institut für Organische Chemie], insges. 1 S.; http://www.esoc.uni-koeln.de/
Fluorinated molecules enable temperature determination in MRS and MRI
In: European Molecular Imaging Meeting, EMIM 2017, April 5 - 7 2017: 12th annual meeting of the ESMI, 2017, PW 02/21, insges. 1 S.; http://esmi-insight.eu/emim2017/contxt/programme/default_session.asp?node=&day=thursday&sessionID=19#session_42
Temperature determination using 19F-substituted molecules
In: ICMRI 2017: the 5th International Congress on Magnetic resonance imaging & 22nd Annual Scientific Meeting of KSMRM : innovative discovery through MRI, March 23 - 25, 2017, Grand Hilton Hotel Seoul, Korea, 2017, SS10-07, insges. 1 S.
Temperature determination via 19F MRS and MRI
In: 39th FGMR Annual Discussion Meeting: Joint Conference of the French and German Magnetic Resonance Societies$dBayreuth, Germany, September 25 - 28, 2017, S. 54
Unified proton and fluorine imaging of small and low spin density samples at a human whole-body 7 T MRI
In: ISMRM 25th annual ISMRM meeting & exhibition, 22 - 27 April 2017: SMRT annual meeting, 22 - 24. April 2017, Honolulu, HI, USA, 2017, Abs. 4405, insges. 2 S.; http://dev.ismrm.org/2017/4405.html
19F-imaging using temperature sensitive 19F-substituted molecules in a 7 T whole-body MRI system
In: Magnetic resonance materials in physics, biology and medicine: MAGMA : the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) - Berlin: Springer, Bd. 30.2017, Suppl. 1, Abstract 423, Seite S404-S405; https://link.springer.com/article/10.1007/s10334-017-0634-z
19F-substituted molecules for temperature sensitive 19F-imaging in a 7 T whole-body MRI system
In: Red hot MRI: fluorine imaging: an informal symposium to discuss and foster collaborative 19F MRI : Berlin 15.+ 16. 10.2017, S. 24; http://www.schlaganfallcentrum.de/fileadmin/redaktion/csb/02_Veranstaltungen/redhotMRI_flyer_web.pdf
SQUID-based ultralow field nuclear magnetic resonance spectroscopy using the para-H2 based hyperpolarization technique SABRE
In: ISMRM 25th annual ISMRM meeting & exhibition, 22 - 27 April 2017: SMRT annual meeting, 22 - 24. April 2017, Honolulu, HI, USA, 2017, Abstract 3033, insges. 2 S.; http://dev.ismrm.org/2017/3033.html
Hyperpolarization of two tyrosine derivatives using photo-CIDNP
In: European Molecular Imaging Meeting, EMIM 2017, April 5 - 7 2017: 12th annual meeting of the ESMI, 2017, PW16/164, insges. 1 S.; http://esmi-insight.eu/emim2017/contxt/programme/default_session.asp?node=34&day=&sessionID=56&bySearch=true&search=hyperpolarization+of#318
LED induced 13C MR signal enhancements in aqueous solution at 7T
In: Magnetic resonance materials in physics, biology and medicine: MAGMA : the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) - Berlin: Springer, Bd. 30.2017, Suppl. 1, Abstract 428, Seite S408-S409; https://link.springer.com/article/10.1007/s10334-017-0634-z
photo-CIDNP for 19F MR amino acid-protein interaction studies in physiological solvents
In: ISMRM 25th annual ISMRM meeting & exhibition, 22 - 27 April 2017: SMRT annual meeting, 22 - 24. April 2017, Honolulu, HI, USA, 2017, Abstract 3036, insges. 2 S.; http://dev.ismrm.org/2017/3036.html
Positive charged nitrogen atom influences polarization transfer in PHIP experiments
In: 39th FGMR Annual Discussion Meeting: Joint Conference of the French and German Magnetic Resonance Societies$dBayreuth, Germany, September 25 - 28, 2017, 2017, Poster 109, S. 211
Examination of the hyperpolarizability of fluorinated nicotinic acids and further pyridine carboxylic acids using SABRE
In: ISMRM 25th annual ISMRM meeting & exhibition, 22 - 27 April 2017: SMRT annual meeting, 22 - 24. April 2017, Honolulu, HI, USA, 2017, Abstract 3038, insges. 2 S.; http://dev.ismrm.org/2017/3038.html
Signal detection of 19F hyperpolarized pyridine derivatives at low and at high magnetic field strengths
In: Red hot MRI: fluorine imaging: an informal symposium to discuss and foster collaborative 19F MRI : Berlin 15.+ 16. 10.2017, S. 25; http://www.schlaganfallcentrum.de/fileadmin/redaktion/csb/02_Veranstaltungen/redhotMRI_flyer_web.pdf
1H, 13C and 19F hyperpolarization of three substituted pyridine derivates
In: Magnetic resonance materials in physics, biology and medicine: MAGMA : the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) - Berlin: Springer, Bd. 30.2017, Suppl. 1, Abstract 675, Seite S634-S635; https://link.springer.com/article/10.1007%2Fs10334-017-0635-y
Begutachteter Zeitschriftenartikel
SQUID-based detection of ultra-low-field multinuclear NMR of substances hyperpolarized using signal amplification by reversible exchange
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Bd. 7.2017, Art.-Nr. 13431, insges. 9 S.; http://dx.doi.org/10.1038/s41598-017-13757-7
2016
Abstrakt
Gas-phase binding study of dodecaborate dianions and receptors with hydrophobic binding pockets
In: MSCEC, Münster, 2016
Decoupling of an 8-channel monopole head coil at 7 tesla
In: ICMRI 2016: the 4th International Congress on MRI & 21st Annual Scientific Meeting of KSMRM, March 24 - 26, 2016, Grand Hilton Hotel Seoul, Korea, (2016), insges. 1 S.
Transmit-/receive system for hi-res micro imaging with 19F contrast agent at 7 T UHF MRI
In: ESMRMB 2016, 33rd Annual Scientific Meeting, Vienna/AT Sept. 29 - Oct. 1 : meeting guide, 2016, Abs. NEWS 9, Seite 115
First hyperpolarization of quaternary pyridinium salts using PHIP
In: Proc. Intl. Soc. Mag. Reson. Med., 2016, 3688
LED induced 19F hyperpolarization in physiological solvent
In: Magnetic resonance materials in physics, biology and medicine : MAGMA : the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB). - Berlin : Springer; Bd. 29 (2016), Suppl. 1, Abs. 155, Seite S148
PHIP of fluorinated quaternary pyridinium ions
In: European Molecular Imaging Meeting, EMIM 2016, 8-10 March: the EMIM 2016 was the 11th annual meeting of the ESMI, 2016, Abs. 92, insges. 1 S.
Improved application of BioEM field simulation software for new B1 transmit concepts at ultra-high field MRI
In: ICMRI 2016: the 4th International Congress on MRI & 21st Annual Scientific Meeting of KSMRM, March 24 - 26, 2016, Grand Hilton Hotel Seoul, Korea, 2016, Abs. SY14-2, insges. 2 S.
Hyperpolarization of fluorinated pyridine carboxylic acids
In: Magnetic resonance materials in physics, biology and medicine: MAGMA : the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) - Berlin: Springer, Bd. 29.2016, Suppl. 1, Abs. 398, Seite S370
Introduction into MRI and MPI technology and methods for molecular imaging
In: European Molecular Imaging Meeting, EMIM 2016, 8-10 March: the EMIM 2016 was the 11th annual meeting of the ESMI, 2016, Abs. 490, insges. 1 S.
LED induced 19F MR signal enhancement at 7T
In: Proc. Intl. Soc. Mag. Reson. Med. 2016, 3684
Temperature dependency of 19F chemical shifts in aqueous solution
In: 38th FGMR Discussion Meeting of the German Magnetic Resonace Society : Düsseldorf, Germany, September 12th to 15th, 2016; (2016), Abs. P20, Seite 100
Begutachteter Zeitschriftenartikel
Evidence for an intrinsic binding force between dodecaborate dianions and receptors with hydrophobic binding pockets
In: Chemical communications: ChemComm - Cambridge: Soc, Bd. 52.2016, 37, S. 6300-6303; http://dx.doi.org/10.1039/c6cc01233g
Buchbeitrag
Hyperpolarization for signal enhancement in fluorine MR applications
In: Fluorine Magnetic Resonance Imaging: Ulrich - Milton: Pan Stanford Publishing, S. 59-102, 2016; http://dx.doi.org/10.1201/9781315364605-4
2015
Abstrakt
Chemical masked dianion [B12F12]- enabled cell labeling
In: Magnetic resonance materials in physics, biology and medicine : (MAGMA) ; the official journal of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB). - Heidelberg : Springer; Bd. 28.2015, Suppl. 1, Abs. 46, S. S35-S36Publikationslink
Artikel in Kongressband
19F-Hyperpolarized Structures as Marker for the Improved Detection of Amyloid Plaques
In: Proc. Intl. Soc. Mag. Reson. Med. 2015, 1878
LED basierte 19F-MR-Signalverstärkung bei 7T
In: Jahrestagung der Deutschen Sektion der ISMRM e.V. - Köln : Dt. Sektion der ISMRM; 18. Jahrestagung 19.-20.11.2015, Münster, V24, S. 116-117Publikationslink
Novel developments in the hyperpolarization of 19F using parahydrogen
In: Joint 5th International DNP Symposium and COST Action EuroHyperPol Final Meeting, Egmond aan Zee (Niederlande), 2015
Parahydrogen Induced Polarization of fluorinated substrates for 19F MR spectroscopy and imaging
In: EMIM, Tübingen, 2015, 127
Parahydrogen Induced Polarization (PHIP) of anticancer drug substructures
In: GDCh – FGMR, Darmstadt (Deutschland), 2015, #78
PHIP hyperpolarization of linear and branched fluorinated alkanes as well as their interaction with cyclodextrins
In: Proc. Intl. Soc. Mag. Reson. Med. 2015, 1879
Untersuchung der Fragmentierungen von auf Cyclen basierenden Ligandensystemen mittels ESI-MS/MS und MS³
In: DGMS, Wuppertal, 2015, PII17
Begutachteter Zeitschriftenartikel
The travelling-wave primate system - a new solution for magnetic resonance imaging of macaque monkeys at 7 Tesla ultra-high field
In: PLOS ONE - San Francisco, California, US: PLOS, Bd. 10.2015, 6, Art. e0129371, insges. 18 S.; http://dx.doi.org/10.1371/journal.pone.0129371
New insights into the old reaction between acryloyl chlorides and pyridine
In: Tetrahedron letters. - Amsterdam [u.a.] : Elsevier Science, Bd. 56.2015, 9, S. 1124-1127Publikationslink
2014
Artikel in Kongressband
Field dependency of parahydrogen induced hyperpolarization (PHIP) of 1H and 19F in earthʾs magnetic field
In: Joint annual meeting ISMRM-ESMRMB. - Milan, S. 2784, 2014Publikationslink
Hyperpolarization of a bisfluorinated phenylalanine derivative using PHIP and examination of the interaction with [beta]-cyclodextrin
In: Joint annual meeting ISMRM-ESMRMB. - Milan, S. 2780, 2014Publikationslink
PHIP hyperpolarization of fluorine: applications, examples and problems
In: European Network for Hyperpolarization Physics and Methodology in NMR and MRI, Zürich, 2014, 48
19F NMR spectroscopy for the study of molecular interactions
In: GDCh – FGMR, Berlin, 2014, P60
19F-Kernspinhyperpolarisation linearer und verzweigter Alkane
In: German Chapter of ISMRM, Jena, 2014
PHIP of valproic acid and related structures
In: Joint annual meeting ISMRM-ESMRMB. - Milan, S. 2781, 2014Publikationslink
Begutachteter Zeitschriftenartikel
Dipolar induced para-hydrogen-induced polarization
In: Solid state nuclear magnetic resonance: an international journal - Orlando, Fla: Academic Press, Bd. 63/64.2014, S. 20-29; http://dx.doi.org/10.1016/j.ssnmr.2014.07.002
Parahydrogen-induced polarization of carboxylic acids: a pilot study of valproic acid and related structures
In: NMR in biomedicine. - New York, NY : Wiley, Bd. 27.2014, 7, S. 810-816Publikationslink
Methacryloyl chloride dimers - from structure elucidation to a manifold of chemical transformations
In: Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry - Amsterdam [u.a.]: Elsevier Science, Bd. 70.2014, 37, S. 6515-6521; http://dx.doi.org/10.1016/j.tet.2014.07.019
2013
Artikel in Kongressband
Hyperpolarisation langkettiger Alkene mittels PHIP
In: German Chapter of ISMRM, ISSN 1863-6365, Freiburg (Deutschland), 2013, page 81
Hyperpolarization of biologically relevant compounds which are important in the GABA metabolism
In: Discovery, innovation & application - advancing mr for improved health , S. 3927, 2013Publikationslink
Hyperpolarized Fluorinated Amino Acid as NMR-based Biomarker
In: ESMRMB 2013, #471, Toulouse (Frankreich)
Begutachteter Zeitschriftenartikel
Parahydrogen-induced polarization transfer to 19F in perfluorocarbons for 19F NMR spectroscopy and MRI
In: Chemistry - a European journal. - Weinheim : Wiley-VCH, Bd. 19.2013, 20, S. 6334-6339Publikationslink
Application of parahydrogen-induced polarization to unprotected dehydroamino carboxylic acids
In: Applied magnetic resonance. - Wien [u.a] : Springer, Bd. 44.2013, 1/2, S. 267-278Publikationslink
Buchbeitrag
Non-invasive high-resolution tracking of human neuronal pathways: diffusion tensor imaging at 7T with 1.2 mm isotropic voxel size
In: Medical imaging 2013. - Bellingham, Wash. : SPIE, insges. 7 S. - (Proceedings of SPIE; 8668)Publikationslink
2012
Artikel in Kongressband
New strategy to hyperpolarize biological relevant molecules containing free amino-groups
In: ESMRMB, Lissabon, 2012, S.60, #222
PHIP hyperpolarized ethanol - overcoming keto-enol tautomerism
In: ESMRMB, Lissabon, 2012, S.60, #224
Synthesis of hyperpolarized Ethanol via PHIP
In: Adapting MR in a changing world, S. 1678, 2012Publikationslink
Originalartikel in begutachteter internationaler Zeitschrift
Parahydrogen induced polarization in face of keto-enol tautomerism: proof of concept with hyperpolarized ethanol
In: Physical chemistry, chemical physics. - Cambridge : The Royal Soc. of Chemistry, Bd. 14.2012, 16, S. 5601-5604Publikationslink
2011
Artikel in Kongressband
Biocompatible 19F Hyperpolarized Semifluorinated alkanes generated via PHIP
In: ESMRMB, Leipzig,2011, S.106, #520
Generating 19F Hyperpolarized Semifluorinated alkanes via Parahydrogen-Transfer
In: SCM, Noordwijk,2011, #06
19F Hyperpolarization of Biocompatible Substrates Generated via Parahydrogen-Transfer
In: ISMRM, Montreal, 2011, #1521, S.179
Dissertation
Synthese und Charakterisierung paramagnetischer Kontrastmittel für die molekulare Bildgebung
In: Shaker Verlag, Aachen, 2011
Originalartikel in begutachteter zeitschriftenartiger Reihe
First step to 19F hyperpolarization of biocompatible substrates generated via parahydrogen-transfer
In: 19th annual ISMRM scientific meeting and exhibition 2011 ; Vol. 2. - Red Hook, NY : Curran, S. 1521Publikationslink
2010
Artikel in Kongressband
Bis(Gd3+-GlyMe-DOTA)-Contrast Agent for 19F-Molecular MR Imaging at 7T
In: WMIC, Kyoto, 2010, #P0937B
Fluorinated contrast agents with cation depending T1 sensitivity
In: Joint Meeting of ISMRM and ESMRMB, Stockholm, 2010, #4225
2009
Artikel in Kongressband
Comparison of different fluorinated AspGlyMe-DOTA- and GluGlyMe-DOTA-Gd-complexes
In: WMIC, Montreal, 2009, #619
New fluorinated Gd-AspGlyMe-DOTA complexes for 19F-MRI
In: ISMRM, Honolulu, 2009, #898
Novel lipophilic fluorinated TPP-Gd-contrast agents
In: ESMRMB, Antalya, 2009, #464
Observation of H/D-exchanges using ESI-MS
In: IMSC, Bremen, 2009, #222
Synthesis of an isotope labelled Gd-complex
In: WMIC, Montreal, 2009, #620
2008
Artikel in Kongressband
Influence of temperature, pH, metalion and ligand system of the 19F-chemical shifts of fluorinated contrast agents
In: ESMRMB, Valencia, 2008, #587
Rat glioma C6 cells labeled with a fluorinated Gd-GlyMe-DOTA-complex
In: ISMRM, Toronto, 2008, #1693
Untersuchung lipophiler Eigenschaften von M3+-Kontrastmitteln mittels HPLC-ESI-MS
In: DGMS, Gießen, 2008, POr69
2007
Artikel in Kongressband
Charakterisierung Gd3+-haltiger Kontrastmittel mittels HPLC-ESI-MS
In: DGMS, Bremen, 2007, # 22
Estimation of lipophilicity of complexes with different lanthanide(III) ions
In: SMI, Providence, 2007, #938
Synthesis and characterisation of fluorinated acyclic and macrocyclic Gd3+-complexes
In: SMI, Providence, 2007, #937
2006
Artikel in Kongressband
Synthesis, characterisation and comparison of 3,5-bistrifluoromethyl substituted phenyl Gd-DTPA- and Gd-DOTA- complexes for 19F-molecular imaging
In: ISFC, Bremen, 2006, # ORG_101
Synthesis and comparison of fluorinated Gd-DTPA- and Gd-DOTA-Contrast agents for 19F-molecular imaging
In: ESMRMB, Warschau, 2006, # 535
2005
Artikel in Kongressband
Fluorinated Gd-DTPA-Contrast Agents for 19F-Molecular MR Imaging
In: SMI, 2005, Köln, # 367
Forschung
Organische Synthese
- Synthese fluorierter ungesättigter Verbindungen
- Synthese von fluorierten Pyridiniumionen
Komplex-/Koordinationschemie und Katalyse
- Synthese und Charakterisierung verschiedener metallorganischer Verbindungen
- Untersuchung von Hydriermechanismen an ungesättigten organischen Verbindungen
NMR-Spektroskopie
- Analyse biologischer Proben mittels NMR mittels der 1D- und 2D-NMR Spektroskopie
- NMR-spektroskopische Stukturaufklärung von organischen und metal-organischen Verbindungen
- NMR-spektroskopische Analyse der Bildung von Gast-Wirtkomplexen im Bereich der Medizinischen Chemie
- Kernspinhyperpolarisation (PHIP, SABRE & photo-CIDNP)
- Untersuchung des Polarisationstranfer von Wasserstoff auf Heterokerne (speziell 19F)
MR-Bildgebung
- MR-Untersuchungen von neuen potentiellen 19F-Kontrastmitteln
Zellkultur
- Zellmarkierung
- Vitalitätsüberprüfungen
Lehre
- Medizinische Informatik (Medizinische Fakultät, OvGU Magdeburg)
- Medizinische Chemie (Universität Bremen)
- Strukturaufklärung Organischer Verbindungen (Universität Bremen)
- Aufnahme NMR-spektroskopischer Daten an einem Bruker WB300 Ultrashield
- Messungen mit 10mm Probenkopf (mit Gradient)
- Kerne: 1H, 13C, 19F, 31P (weitere möglich)
- 2D-NMR Spektren: HH-COSY, HSQC, HMBC (weitere möglich)
- Auswertung 1D- und 2D-NMR Spektren zur Analyse bzw. Strukturaufklärung
- Vitalitätsstudien/Zellkultur